Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation
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چکیده
منابع مشابه
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.
Amyloidogenesis defines a condition in which a soluble and innocuous protein turns to insoluble protein aggregates known as amyloid fibrils. This protein suprastructure derived via chemically specific molecular self-assembly process has been commonly observed in various neurodegenerative disorders such as Alzheimer's, Parkinson's, and Prion diseases. Although the major culprit for the cellular ...
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Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many human diseases, including Alzheimer's, Creutzfeld-Jacob disease, and dialysis-related amyloidosis. Fibril formation occurs by nucleation-dependent kinetics, wherein formation of a critical nucleus is the key ra...
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متن کاملFrom the Cover: Nucleation of protein fibrillation by nanoparticles
If you believe this document infringes copyright then please contact the KAR admin team with the take-down information provided at http://kar.kent.ac.uk/contact.html Citation for published version Linse, Sara and Cabaleiro-Lago, Celia and Xue, Wei-Feng and Lynch, Iseult and Lindman, Stina and Thulin, Eva and Radford, Sheena E. and Dawson, Kenneth A (2007) Nucleation of protein fibrillation by n...
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• Two general theories of cardiac fibrillation currently prevail: the circus movement theory of Garrey and Lewis, and the ectopic focus theory of Sherf and Prinzmetal. Surprisingly, little systematic work has been done to establish whether either of these theories applies to the cardiac fibrillation that occurs spontaneously when mammals are cooled. The circus movement theory postulates repetit...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2009
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2009.42.9.541